To take account for an increasing need for a knowledge based material and device design, there is a high demand for analytical investigations on an atomic scale. The work in our group aims to understand processes at organic, inorganic and hybrid interfaces that are relevant for the performance of optoelectronic devices such as solar cells or light emitting diodes. Within our projects, we apply scanning probe microscopy methods with a focus on non-contact atomic force microscopy (nc-AFM), where we perform local force spectroscopy, energy dissipation, and contact potential difference measurements. Furthermore, our instrumentation allows to record tunneling currents, which enables us to perform simultaneous nc-AFM and scanning tunneling microscopy (STM) measurements. We utilize the different topographic and spectroscopic information channels to gain access to the interface properties with a spatial resolution down to the picometer range. The investigations are performed under ultrahigh vacuum (UHV) conditions and at low temperatures to establish highly defined experimental conditions.